Reliability of MIBG myocardial scintigraphy in the diagnosis of Parkinson's disease

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Neurological applications for myocardial MIBG scintigraphy.

Signs or symptoms of impaired autonomic regulation of circulation are typically present in patients affected by Parkinson's disease (PD), in agreement with the cardiac sympathetic denervation discovered by Goldstein more than 15 yrs. ago. In particular, the majority of PD patients have a diffuse left ventricular myocardial sympathetic denervation, being a normal neurological condition present o...

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Background: Iodine-123 metaiodobenzylguanidine (123I-MIBG) myocardial scintigraphy has been accepted as one of the most useful methods for the diagnosis of Parkinson’s disease (PD). Moreover, the accumulated evidence has indicated that the heart-to-mediastinum (H/M) ratio correlates with the disease severity of hypokinesia/ bradykinesia and rigidity. The present report describes the wearing-off...

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ژورنال

عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry

سال: 2005

ISSN: 0022-3050

DOI: 10.1136/jnnp.2004.037028